The concept of a 'mechanism-based taxonomy of human disease' is currently replacing the outdated paradigm of diseases classified by clinical appearance. We have tackled the paradigm of mechanism-based patient subgroup identification in the challenging area of research on neurodegenerative diseases.

We have developed mechanistic knowledge graphs representing essential pathophysiology mechanisms for multiple conditions . Together with dedicated-algorithms, Neuro-PsychoMMSig forms the basis for a 'mechanism-enrichment server' that supports the mechanistic interpretation of multiscale, multimodal clinical data.